Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
USERS' SCORE
Moderately Good
Based on 70 Reviews
7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Biotin
10,000 mcg
33,333%
Calcium (as Dibasic Calcium Phosphate)
66 mg
5%
Top Medical Research Studies
7
We evaluated the effectiveness of high-dose biotin in treating multiple sclerosis through a systematic review of randomized controlled trials.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Read More
7
We evaluated the effectiveness of high-dose pharmaceutical-grade biotin (MD1003) in enhancing treatment responses for patients with progressive multiple sclerosis (PMS). Over one year, we monitored 48 newly treated patients, using clinical assessments and brain volume metrics.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Read More
8
Dexamethasone delivery variations studied
We explored how different linkers and lengths in biotin-dexamethasone conjugates affect drug delivery to the liver, particularly in autoimmune hepatitis. Through in vitro and in vivo studies, we noted that certain combinations enhance drug stability and uptake in liver cells.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Read More
Most Useful Reviews
9
Nail growth
8 people found this helpful
I received this product in a week and am beginning my journey with it. A friend with an autoimmune disorder saw excellent eyelash growth, so I’m excited about my own results as well. My nails are already growing faster, and I can't wait to see more improvements!
Read More
9
Hair growth
8 people found this helpful
The results have been impressive! I ordered this as my hair was falling out significantly. After three months, I barely noticed any loss, and others remarked on my hair's thickness. My nails have also strengthened considerably, and there were no side effects. I highly recommend it.
Read More
10
Restored hair growth
6 people found this helpful
Biotin 10,000 mg is fantastic! After having COVID-19, I faced severe hair loss, but after following my doctor’s advice to take this supplement, my hair stopped falling out, and I noticed new growth. I'm very pleased!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.4
- All Researches
9
We explored the unusual manifestations of biotinidase deficiency (BTD), showcasing three cases initially diagnosed as neuromyelitis optica spectrum disorder (NMOSD).
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
Read More
9
We observed a fascinating case of a four-year-old girl diagnosed with Thiamine Metabolism Dysfunction Syndrome 5 and acute disseminated encephalomyelitis, who exhibited marked improvement after treatment with biotin and thiamine. Initially presenting with fever and agitation post-vaccination, genetic tests later revealed a pathogenic variant in the TPK1 gene. The girl's clinical status improved significantly, with resolution of autism spectrum disorder symptoms, supporting the role of early intervention. This case strengthens the evidence for biotin and thiamine in treating metabolic deficiencies related to TPK1.
Read More
8
Dexamethasone delivery variations studied
We explored how different linkers and lengths in biotin-dexamethasone conjugates affect drug delivery to the liver, particularly in autoimmune hepatitis. Through in vitro and in vivo studies, we noted that certain combinations enhance drug stability and uptake in liver cells.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Our findings suggest that tweaking the construction of these nanoparticles can meaningfully influence how effectively the drug works in the body. This could lead to better steroid formulations tailored for various medical needs.
Read More
8
We explored two intriguing cases of biotinidase deficiency, a rare genetic disorder that can mimic conditions like Neuromyelitis Optica Spectrum Disorder. Initially, both patients received treatments for immune-mediated disorders, but when their symptoms worsened, further testing revealed biotinidase deficiency.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
Remarkably, after starting biotin supplementation, both children showed significant improvement. This highlights the importance of recognizing atypical neurological signs, as early diagnosis and treatment of biotinidase deficiency can lead to effective intervention.
Read More
7
We set out to examine the effects of high-dose pharmaceutical-grade biotin on patients with different types of demyelinating neuropathies.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
In a pilot study involving 15 participants, we aimed to see if this treatment could improve various nerve function measures.
While the main goal of achieving a 10% improvement in specific nerve conduction measurements wasn’t reached, many participants showed better sensory and motor abilities.
Overall, these findings suggest that high-dose biotin might help in some ways, and the treatment was well-tolerated by participants.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 70 Reviews
7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Nail growth
8 people found this helpful
I received this product in a week and am beginning my journey with it. A friend with an autoimmune disorder saw excellent eyelash growth, so I’m excited about my own results as well. My nails are already growing faster, and I can't wait to see more improvements!
Read More
9
Hair growth
8 people found this helpful
The results have been impressive! I ordered this as my hair was falling out significantly. After three months, I barely noticed any loss, and others remarked on my hair's thickness. My nails have also strengthened considerably, and there were no side effects. I highly recommend it.
Read More
10
Restored hair growth
6 people found this helpful
Biotin 10,000 mg is fantastic! After having COVID-19, I faced severe hair loss, but after following my doctor’s advice to take this supplement, my hair stopped falling out, and I noticed new growth. I'm very pleased!
Read More
9
Stopped hair loss
6 people found this helpful
I took this when my hair was growing poorly and falling out. I started with one a day for two months, then half for another two months. After a month, the hair loss stopped, and new growth began. I continue to take it weekly to maintain the effect. This biotin is excellent; it helped greatly against hair loss, and the price is fantastic!
Read More
10
Effective treatment
4 people found this helpful
Biotin has been remarkable! My hair shedding, caused by an autoimmune disorder, stopped within just five days of taking it. I’m unsure how it worked so quickly, but it's now my go-to remedy!
Read More
Frequently Asked Questions
10
Effective treatment
4 people found this helpful
Biotin has been remarkable! My hair shedding, caused by an autoimmune disorder, stopped within just five days of taking it. I’m unsure how it worked so quickly, but it's now my go-to remedy!
7.5
Significant improvement
1 people found this helpful
Great, my hair has stopped falling out after taking biotin for three weeks. Initially, I had concerns about pimples appearing, but they're quickly gone. The decrease in hair loss is worth it, and I consider this dietary supplement to be excellent value for money.
9
Hair growth
8 people found this helpful
The results have been impressive! I ordered this as my hair was falling out significantly. After three months, I barely noticed any loss, and others remarked on my hair's thickness. My nails have also strengthened considerably, and there were no side effects. I highly recommend it.
9
Stopped hair loss
6 people found this helpful
I took this when my hair was growing poorly and falling out. I started with one a day for two months, then half for another two months. After a month, the hair loss stopped, and new growth began. I continue to take it weekly to maintain the effect. This biotin is excellent; it helped greatly against hair loss, and the price is fantastic!
9
Nail growth
8 people found this helpful
I received this product in a week and am beginning my journey with it. A friend with an autoimmune disorder saw excellent eyelash growth, so I’m excited about my own results as well. My nails are already growing faster, and I can't wait to see more improvements!
9
Significant improvement
22 people found this helpful
I'm ordering this biotin for the second time as it significantly improved my hair health, making it thick and healthy. My nails also grew longer in just two months, which is impressive.
10
Less hair loss
3 people found this helpful
After giving birth, I experienced significant hair shedding due to an autoimmune disorder. Biotin reduced the loss after half a month. With added omega-3, the results are fantastic—my hair no longer falls out and my eyelashes have grown longer!
9
Skin condition improved
3 people found this helpful
I ordered biotin for my son's seborrhoeic dermatitis. Initially, dermatology suggested steroid treatments. After taking it with vitamin C, I saw marked improvement; redness subsided and my skin changed positively. I started taking it too and noticed my nails were healthier.
0
Negative side effects
11 people found this helpful
Be cautious; while some may benefit, I faced negative reactions from the biotin. It caused subcutaneous pimples, worsened hair loss, and nails that broke less but didn't grow. Despite the promise, it caused issues for me with my autoimmune disorder.
7
We evaluated the effectiveness of high-dose biotin in treating multiple sclerosis through a systematic review of randomized controlled trials.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
Our findings suggest that patients could see some benefit from using high-dose biotin over a period of 12 to 15 months.
However, it's important to note that this potential upside comes with a notable downside: an increased likelihood of affecting laboratory test results.
Overall, the evidence remains moderately certain, indicating a cautious approach is necessary for those considering biotin treatment for multiple sclerosis.
7
We evaluated the effectiveness of high-dose pharmaceutical-grade biotin (MD1003) in enhancing treatment responses for patients with progressive multiple sclerosis (PMS). Over one year, we monitored 48 newly treated patients, using clinical assessments and brain volume metrics.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
Encouragingly, 27% of patients experienced a notable reduction in disability scores. Additionally, improvements in brain and cervical spinal cord volume were observed in several patients. Yet, those with higher levels of neurofilament light chains or older age at MS onset appeared to have less positive responses to treatment.
9
We explored the unusual manifestations of biotinidase deficiency (BTD), showcasing three cases initially diagnosed as neuromyelitis optica spectrum disorder (NMOSD).
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
These patients exhibited severe symptoms such as quadriplegia and vision loss. Although some responded to immune therapy initially, they relapsed, while one did not improve at all.
Following further testing, it became clear that BTD was the true culprit. Remarkably, two patients experienced significant recovery after starting biotin supplementation, highlighting the potential of biotin in treating this deficiency.
References
- Ali F, Mukhtiar K, Raza M, Ibrahim S. Atypical presentation of biotinidase deficiency: masquerading neuromyelitis optica spectrum disorder. BMJ Case Rep. 2024;17. doi:10.1136/bcr-2023-258703
- Créange A, Hutin E, Sedel F, Le Vigouroux L, Lefaucheur JP. High-dose pharmaceutical-grade biotin in patients with demyelinating neuropathies: a phase 2b open label, uncontrolled, pilot study. BMC Neurol. 2023;23:389. doi:10.1186/s12883-023-03440-y
- Thompson ZE, Boyd NK, Khoshnood MM, Santoro JD. Thiamine metabolism dysfunction syndrome 5 (THMD5) mimicking acute disseminated encephalomyelitis. Am J Med Genet A. 2023;191:2868. doi:10.1002/ajmg.a.63376
- Ongaro A, Violatto MB, Casarin E, Pellerani I, Marchini G, et al. The mode of dexamethasone decoration influences avidin-nucleic-acid-nano-assembly organ biodistribution and in vivo drug persistence. Nanomedicine. 2022;40:102497. doi:10.1016/j.nano.2021.102497
- Espiritu AI, Remalante-Rayco PPM. High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials. Mult Scler Relat Disord. 2021;55:103159. doi:10.1016/j.msard.2021.103159
- Collongues N, Kuhle J, Tsagkas C, Lamy J, Meyer N, et al. Biomarkers of treatment response in patients with progressive multiple sclerosis treated with high-dose pharmaceutical-grade biotin (MD1003). Brain Behav. 2021;11:e01998. doi:10.1002/brb3.1998
- Mathais S, Moisset X, Pereira B, Taithe F, Ciron J, et al. Relapses in Patients Treated with High-Dose Biotin for Progressive Multiple Sclerosis. Neurotherapeutics. 2021;18:378. doi:10.1007/s13311-020-00926-2
- Shah S, Khan N, Lakshmanan R, Lewis B, Nagarajan L. Biotinidase deficiency presenting as Neuromyelitis Optica Spectrum Disorder. Brain Dev. 2020;42:762. doi:10.1016/j.braindev.2020.07.007
